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Product Description
DKK2 Antibody [AMM22258G] | Leading Biology
Product Category: Monoclonal Antibodies
Host: Mouse
Species Reactivity: H, M
Specificity: This DKK2 antibody is generated from a mouse immunized with a recombinant protein of human DKK2.
Cellular Localisation: Secreted.
Molecular Weight: 28447
Clone: Monoclonal
Gene Name: DKK2
Gene ID: 27123
Function: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity) .
Summary: Tissue Location: Expressed in heart, brain, skeletal muscle and lung
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:2000
Synonyms: Dickkopf-related protein 2, Dickkopf-2, Dkk-2, hDkk-2, DKK2
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