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Product Description
NLRP12 Antibody [AMM22115G] | Leading Biology
Product Category: Monoclonal Antibodies
Host: Mouse
Species Reactivity: M
Specificity: This NLRP12 monoclonal antibody is generated from mouse immunized with NLRP12 recombinant protein.
Cellular Localisation: Cytoplasm.
Molecular Weight: 120173
Clone: Monoclonal
Gene Name: NLRP12
Gene ID: 91662
Function: Plays an essential role as an potent mitigator of inflammation (PubMed:30559449) . Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways (PubMed:15489334, PubMed:17947705) . Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway (PubMed:30559449) . In turn, promotes bacterial tolerance (PubMed:30559449) . Inhibits also the DDX58-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked DDX58 activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked DDX58 degradation (PubMed:30902577) . Acts also as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue (By similarity) .
Summary: Tissue Location: Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.
Form: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:500
Synonyms: NACHT, LRR and PYD domains-containing protein 12, Monarch-1, PYRIN-containing APAF1-like protein 7, Regulated by nitric oxide, NLRP12, NALP12, PYPAF7, RNO
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