Euro
USD
British Pound
NULL
![POU2AF1 Antibody [AMM02477G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/869235/1161302/logo__92149.1659788186__06222.1659865475.png?c=2 "POU2AF1 Antibody [AMM02477G]"){kind=logo}
![POU2AF1 Antibody [AMM02477G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/869235/1161302/logo__92149.1659788186__06222.1659865475.png?c=2 "POU2AF1 Antibody [AMM02477G]"){kind=logo}
Product Description
POU2AF1 Antibody [AMM02477G] | Leading Biology
Product Category: Monoclonal Antibodies
Host: Mouse
Species Reactivity: H
Specificity: Purified His-tagged POU2AF1 protein was used to produced this monoclonal antibody.
Cellular Localisation: Nucleus.
Molecular Weight: 27436
Clone: Monoclonal
Gene Name: POU2AF1 (HGNC:9211)
Gene ID: 5450
Function: Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2 (PubMed:7859290) . It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2 (PubMed:7779176) . It has no intrinsic DNA-binding activity. It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2 (PubMed:7779176) . It is essential for the response of B-cells to antigens and required for the formation of germinal centers (PubMed:7623806, PubMed:7859290) . Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator (By similarity) .
Summary: Tissue Location: B-cell specific (PubMed:7779176, PubMed:7859290) . Detected in mainly in spleen, but also in thymus, periphral blood leukocyte and small intestine (PubMed:7779176, PubMed:7859290)
Form: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:4000
Synonyms: POU domain class 2-associating factor 1, B-cell-specific coactivator OBF-1, BOB-1, OCA-B, OCT-binding factor 1, POU2AF1, OBF1
![POU2AF1 Antibody [AMM02477G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/869235/1161302/logo__92149.1659788186__06222.1659865475.png?c=2 "POU2AF1 Antibody [AMM02477G]"){kind=logo}
