Euro
USD
British Pound
NULL
![TP63 Antibody (Ascites) [AMM02433G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/863739/1155806/logo__92149.1659788186__06842.1659859883.png?c=2 "TP63 Antibody (Ascites) [AMM02433G]"){kind=logo}
![TP63 Antibody (Ascites) [AMM02433G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/863739/1155806/logo__92149.1659788186__06842.1659859883.png?c=2 "TP63 Antibody (Ascites) [AMM02433G]"){kind=logo}
Product Description
TP63 Antibody (Ascites) [AMM02433G] | Leading Biology
Product Category: Monoclonal Antibodies
Host: Mouse
Species Reactivity: H
Specificity: This TP63 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 651-680 amino acids from human TP63.
Cellular Localisation: Nucleus
Molecular Weight: 76785
Clone: Monoclonal
Gene Name: TP63
Gene ID: 8626
Function: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.
Summary: Tissue Location: Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues
Form: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:200~1600
Synonyms: Tumor protein 63, p63, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor KET, Transformation-related protein 63, TP63, Tumor protein p73-like, p73L, p40, p51, TP63, KET, P63, P73H, P73L, TP73L
![TP63 Antibody (Ascites) [AMM02433G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/863739/1155806/logo__92149.1659788186__06842.1659859883.png?c=2 "TP63 Antibody (Ascites) [AMM02433G]"){kind=logo}
