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![VRK1 Antibody (Center) (Ascites) [AMM02470G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/869191/1161258/logo__92149.1659788186__77957.1659865441.png?c=2 "VRK1 Antibody (Center) (Ascites) [AMM02470G]"){kind=logo}
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Product Description
VRK1 Antibody (Center) (Ascites) [AMM02470G] | Leading Biology
Product Category: Monoclonal Antibodies
Host: Mouse
Species Reactivity: H
Specificity: Purified His-tagged VRK1 protein was used to produced this monoclonal antibody.
Cellular Localisation: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Dispersed throughout the cell but not located on mitotic spindle or chromatids during mitosis
Molecular Weight: 45476
Clone: Monoclonal
Gene Name: VRK1
Gene ID: 7443
Function: Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain- containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.
Summary: Tissue Location: Widely expressed. Highly expressed in fetal liver, testis and thymus.
Form: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:5000
Synonyms: Serine/threonine-protein kinase VRK1, Vaccinia-related kinase 1, VRK1
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