Euro
USD
British Pound
NULL
![EIF3CL Antibody (N-term) [APR30984G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/871229/1163296/logo__92149.1659788186__66497.1659867978.png?c=2 "EIF3CL Antibody (N-term) [APR30984G]"){kind=logo}
![EIF3CL Antibody (N-term) [APR30984G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/871229/1163296/logo__92149.1659788186__66497.1659867978.png?c=2 "EIF3CL Antibody (N-term) [APR30984G]"){kind=logo}
Product Description
EIF3CL Antibody (N-term) [APR30984G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This EIF3CL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-155 amino acids from the N-terminal region of human EIF3CL.
Cellular Localisation: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03002}.
Molecular Weight: 105344
Clone: Polyclonal
Gene Name: EIF3C {ECO:0000255|HAMAP-Rule:MF_03002}
Gene ID: 8663
Function: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815) . The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl- tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC) . The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632) . The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773) .
Summary: N/A
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: IHC-P, FC, WB
Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50
Synonyms: Eukaryotic translation initiation factor 3 subunit C {ECO:0000255|HAMAP-Rule:MF_03002}, eIF3c {ECO:0000255|HAMAP-Rule:MF_03002}, Eukaryotic translation initiation factor 3 subunit 8 {ECO:0000255|HAMAP-Rule:MF_03002}, eIF3 p110 {ECO:0000255|HAMAP-Rule:MF_03002}, EIF3C {ECO:0000255|HAMAP-Rule:MF_03002}
![EIF3CL Antibody (N-term) [APR30984G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/871229/1163296/logo__92149.1659788186__66497.1659867978.png?c=2 "EIF3CL Antibody (N-term) [APR30984G]"){kind=logo}
![ATP1A4 Antibody (N-Term) [APR33587G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/873832/1165899/logo__92149.1659788186__80810.1659869218.png?c=2 "ATP1A4 Antibody (N-Term) [APR33587G]"){kind=logo}
![RPLP1 Antibody (N-Term) [APR33434G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/873679/1165746/logo__92149.1659788186__53782.1659869157.png?c=2 "RPLP1 Antibody (N-Term) [APR33434G]"){kind=logo}
![H2AFX Antibody (N-term) [AMM22155G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/870516/1162583/logo__92149.1659788186__96231.1659866659.png?c=2 "H2AFX Antibody (N-term) [AMM22155G]"){kind=logo}
![FUBP3 Antibody (N-term) [AMM22160G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/870521/1162588/logo__92149.1659788186__98749.1659866662.png?c=2 "FUBP3 Antibody (N-term) [AMM22160G]"){kind=logo}
![CCT8L2 Antibody (N-Term) [ApR04986G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/870252/1162319/logo__92149.1659788186__06532.1659866438.png?c=2 "CCT8L2 Antibody (N-Term) [ApR04986G]"){kind=logo}
![PGAM2 Antibody (N-term) [APR30620G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/870865/1162932/logo__92149.1659788186__93271.1659866947.png?c=2 "PGAM2 Antibody (N-term) [APR30620G]"){kind=logo}
![CRCT1 Antibody (N-term) [APR30534G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/870779/1162846/logo__92149.1659788186__11838.1659866876.png?c=2 "CRCT1 Antibody (N-term) [APR30534G]"){kind=logo}