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Product Description
HPN Antibody (Center) [ApR04812G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This HPN antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 153-188 amino acids from the Central region of human HPN.
Cellular Localisation: Cell membrane; Single-pass type II membrane protein Apical cell membrane; Single-pass type II membrane protein
Molecular Weight: 45011
Clone: Polyclonal
Gene Name: HPN
Gene ID: 3249
Function: Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:21875933, PubMed:15839837) . Plays a role in cell growth and maintenance of cell morphology (PubMed:8346233, PubMed:21875933) . Plays a role in the proteolytic processing of ACE2 (PubMed:24227843) . Mediates the proteolytic cleavage of urinary UMOD that is required for UMOD polymerization (PubMed:26673890) .
Summary: Tissue Location: Detected in liver and kidney.
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:2000
Synonyms: Serine protease hepsin, Transmembrane protease serine 1, Serine protease hepsin non-catalytic chain, Serine protease hepsin catalytic chain, HPN, TMPRSS1
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