Product Description
IGF2 Antibody (Center R54) [APR03540G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M
Specificity: This IGF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-68 amino acids from the Central region of human IGF2.
Cellular Localisation: Secreted.
Molecular Weight: 20140
Clone: Polyclonal
Gene Name: IGF2
Gene ID: 3481
Function: The insulin-like growth factors possess growth-promoting activity (By similarity) . Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable) . Acts as a ligand for integrin which is required for IGF2 signaling (PubMed:28873464) . Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity) . Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity) .
Summary: Tissue Location: Expressed in heart, placenta, lung, liver, muscle, kidney, tongue, limb, eye and pancreas.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: IHC-P, WB, FC
Dilution: FC--1:25 WB--1:2000
Synonyms: Insulin-like growth factor II, IGF-II, Somatomedin-A, Insulin-like growth factor II, Insulin-like growth factor II Ala-25 Del, Preptin, IGF2