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Product Description
Metabotropic Glutamate Receptor 1 Antibody (C-term) [AMM06381G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This Metabotropic Glutamate Receptor 1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1096-1126 amino acids from the C-terminal region of human Metabotropic Glutamate Receptor 1.
Cellular Localisation: Cell membrane; Multi-pass membrane protein
Molecular Weight: 132357
Clone: Polyclonal
Gene Name: GRM1
Gene ID: 2911
Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol- calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (PubMed:24603153, PubMed:28886343, PubMed:7476890) . May function in the light response in the retina (By similarity) .
Summary: Tissue Location: Detected in brain.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: IHC-P, WB
Dilution: WB--1:1000 IHC-P--1:100~500
Synonyms: Metabotropic glutamate receptor 1, mGluR1, GRM1, GPRC1A, MGLUR1
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