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![(Mouse) Sox2 Antibody (N-term) [AMM08738G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/869770/1161837/logo__92149.1659788186__96964.1659865905.png?c=2 "(Mouse) Sox2 Antibody (N-term) [AMM08738G]"){kind=logo}
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Product Description
(Mouse) Sox2 Antibody (N-term) [AMM08738G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This Mouse Sox2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 34-68 amino acids from the N-terminal region of mouse Sox2.
Cellular Localisation: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:17097055, ECO:0000269|PubMed:32127020}
Molecular Weight: 34454
Clone: Polyclonal
Gene Name: Sox2
Gene ID: 20674
Function: Transcription factor that forms a trimeric complex with POU5F1 (OCT3/4) on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (PubMed:15863505, PubMed:17097055, PubMed:19740739) . Binds to the proximal enhancer region of NANOG (PubMed:15863505) . Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity) . Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (PubMed:22198669) . Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity) . May function as a switch in neuronal development (By similarity) .
Summary: Tissue Location: Expressed in the cochlea (at protein level) (PubMed:32127020) . Expressed in the brain and retina (PubMed:7590241, PubMed:15863505) . A very low level of expression is seen in the stomach and lung (PubMed:7590241, PubMed:15863505) . Expressed in the kidney (PubMed:15863505) .
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Transcription factor SOX-2, Sox2, Sox-2
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