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Product Description
PPAP2A Antibody (C-term) [AMR09441G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This PPAP2A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 270-304 amino acids from the C-terminal region of human PPAP2A.
Cellular Localisation: Cell membrane; Multi-pass membrane protein Apical cell membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein. Membrane, caveola {ECO:0000250|UniProtKB:Q61469}; Multi-pass membrane protein
Molecular Weight: 32156
Clone: Polyclonal
Gene Name: PLPP1 (HGNC:9228)
Gene ID: 8611
Function: Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P (PubMed:9305923, PubMed:9705349, PubMed:9607309, PubMed:10962286, PubMed:17379599) . Also acts on N-oleoyl ethanolamine phosphate/N- (9Z-octadecenoyl) -ethanolamine phosphate, a potential physiological compound (PubMed:9607309) . Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes (PubMed:10962286, PubMed:12909631, PubMed:15461590, PubMed:17379599) . It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P (PubMed:17379599) . Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes (PubMed:12909631, PubMed:15461590) . May also have an intracellular activity to regulate phospholipid- mediated signaling pathways (By similarity) .
Summary: Tissue Location: Widely expressed with highest expression found in prostate (PubMed:9305923) . Found to be down-regulated in colon adenocarcinomas (PubMed:9570154) . [Isoform 2]: Predominant in heart and pancreas.
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Lipid phosphate phosphohydrolase 1, PAP2-alpha, Phosphatidate phosphohydrolase type 2a, Phosphatidic acid phosphatase 2a, PAP-2a, PAP2a, PPAP2A, LPP1
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