Product Description
PSME4 Antibody (N-Term) [ApR04975G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This PSME4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 503-535 amino acids from human PSME4.
Cellular Localisation: Cytoplasm, cytosol. Nucleus. Nucleus speckle Note=Found in nuclear foci following treatment with ionizing radiation, but not with ultraviolet irradiation or H (2) O (2)
Molecular Weight: 211334
Clone: Polyclonal
Gene Name: PSME4
Gene ID: 23198
Function: Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.
Summary: N/A
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:2000
Synonyms: Proteasome activator complex subunit 4, Proteasome activator PA200, PSME4, KIAA0077