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Product Description
TFDP2 Antibody (Center) [ApR04888G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This TFDP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 175-208 amino acids from the Central region of human TFDP2.
Cellular Localisation: Nucleus.
Molecular Weight: 49236
Clone: Polyclonal
Gene Name: TFDP2
Gene ID: 7029
Function: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell- cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters (PubMed:20176812) .
Summary: Tissue Location: High levels in heart and skeletal muscle. Also found in placenta, kidney, brain, lung and liver. The presence as well as the abundance of the different transcripts appear to vary significantly in different tissues and cell lines
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:2000
Synonyms: Transcription factor Dp-2, E2F dimerization partner 2, TFDP2, DP2
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