Product Description
CLPX Antibody (C-term) [APR07092G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This CLPX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 449-477 amino acids from the C-terminal region of human CLPX.
Cellular Localisation: Mitochondrion. Mitochondrion matrix, mitochondrion nucleoid
Molecular Weight: 69224
Clone: Polyclonal
Gene Name: CLPX
Gene ID: 10845
Function: ATP-dependent specificity component of the Clp protease complex. Hydrolyzes ATP (PubMed:28874591) . Targets specific substrates for degradation by the Clp complex (PubMed:11923310, PubMed:22710082) . Can perform chaperone functions in the absence of CLPP. Enhances the DNA-binding activity of TFAM and is required for maintaining a normal mitochondrial nucleoid structure (PubMed:22841477) . ATP-dependent unfoldase that stimulates the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5- aminolevulinate (ALA) synthesis, the first step in heme biosynthesis (PubMed:28874591) . Important for efficient erythropoiesis through upregulation of heme biosynthesis (PubMed:25957689, PubMed:28874591) .
Summary: Tissue Location: Higher expression in skeletal muscle and heart and to a lesser extent in liver, brain, placenta, lung, kidney and pancreas.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: IHC-P, FC, WB
Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50
Synonyms: ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial, CLPX