Euro
USD
British Pound
NULL
![KLHL3 Antibody (Center) [APR04181G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/865654/1157721/logo__92149.1659788186__83692.1659862555.png?c=2 "KLHL3 Antibody (Center) [APR04181G]"){kind=logo}
![KLHL3 Antibody (Center) [APR04181G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/865654/1157721/logo__92149.1659788186__83692.1659862555.png?c=2 "KLHL3 Antibody (Center) [APR04181G]"){kind=logo}
Product Description
KLHL3 Antibody (Center) [APR04181G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This KLHL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 207-234 amino acids from the Central region of human KLHL3.
Cellular Localisation: Cytoplasm, cytoskeleton. Cytoplasm, cytosol
Molecular Weight: 64970
Clone: Polyclonal
Gene Name: KLHL3 {ECO:0000303|PubMed:10843806, ECO:0000312|HGNC:HGNC:6354}
Gene ID: 26249
Function: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron (PubMed:14528312, PubMed:22406640, PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031) . The BCR (KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031) . The BCR (KLHL3) complex also mediates ubiquitination and degradation of CLDN8, a tight- junction protein required for paracellular chloride transport in the kidney (By similarity) .
Summary: Tissue Location: Widely expressed..
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Kelch-like protein 3, KLHL3, KIAA1129
![KLHL3 Antibody (Center) [APR04181G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/865654/1157721/logo__92149.1659788186__83692.1659862555.png?c=2 "KLHL3 Antibody (Center) [APR04181G]"){kind=logo}
