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Product Description
LAT2 Antibody (Center) [APR17173G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This LAT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-135 amino acids from the Central region of human LAT2.
Cellular Localisation: Cell membrane; Single-pass type III membrane protein Note=Present in lipid rafts
Molecular Weight: 26550
Clone: Polyclonal
Gene Name: LAT2
Gene ID: 7462
Function: Involved in FCER1 (high affinity immunoglobulin epsilon receptor) -mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor) -mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I) -mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
Summary: Tissue Location: Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level)
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Linker for activation of T-cells family member 2, Linker for activation of B-cells, Membrane-associated adapter molecule, Non-T-cell activation linker, Williams-Beuren syndrome chromosomal region 15 protein, Williams-Beuren syndrome chromosomal region 5 protein, LAT2, LAB, NTAL, WBS15, WBSCR15, WBSCR5
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