Euro
USD
British Pound
NULL
![MMP2 Antibody (Center) [APR07015G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/864815/1156882/logo__92149.1659788186__40479.1659862212.png?c=2 "MMP2 Antibody (Center) [APR07015G]"){kind=logo}
![MMP2 Antibody (Center) [APR07015G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/864815/1156882/logo__92149.1659788186__40479.1659862212.png?c=2 "MMP2 Antibody (Center) [APR07015G]"){kind=logo}
Product Description
MMP2 Antibody (Center) [APR07015G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This MMP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 303-331 amino acids from the Central region of human MMP2.
Cellular Localisation: [Isoform 1]: Secreted, extracellular space, extracellular matrix. Membrane. Nucleus Note=Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes
Molecular Weight: 73882
Clone: Polyclonal
Gene Name: MMP2
Gene ID: 4313
Function: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta- type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14. [Isoform 2]: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial- nuclear stress signaling with activation of the pro-inflammatory NF- kappaB, NFAT and IRF transcriptional pathways.
Summary: Tissue Location: Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: 72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A, Matrix metalloproteinase-2, MMP-2, TBE-1, PEX, MMP2, CLG4A
![MMP2 Antibody (Center) [APR07015G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/864815/1156882/logo__92149.1659788186__40479.1659862212.png?c=2 "MMP2 Antibody (Center) [APR07015G]"){kind=logo}
![MMP2 Antibody [MMP2/1501]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/575446/812174/porsci_lo__79508.1648973713__06471.1649091928.png?c=2 "MMP2 Antibody [MMP2/1501]")
