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Product Description
Puma BH3 Domain Antibody [APR07168G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This Puma BH3 Domain antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 119-154 amino acids from human Puma BH3 Domain.
Cellular Localisation: Mitochondrion Note=Localized to the mitochondria in order to induce cytochrome c release
Molecular Weight: 20532
Clone: Polyclonal
Gene Name: BBC3
Gene ID: 27113
Function: Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis (PubMed:11463391) . Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis (PubMed:23340338) .
Summary: Tissue Location: Ubiquitously expressed.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P, IF, FC
Dilution: WB--1:1000 IHC-P--1:100~500 IF--1:10~50 FC--1:10~50
Synonyms: Bcl-2-binding component 3, JFY-1, p53 up-regulated modulator of apoptosis, BBC3, PUMA
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