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Product Description
L3MBTL1 Antibody (Center) [APR33355G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: M
Specificity: This L3MBTL1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 451-485 amino acids from the Central region of human L3MBTL1.
Cellular Localisation: Nucleus. Note=Excluded from the nucleolus. Does not colocalizes with the PcG protein BMI1, suggesting that these two proteins do not belong to the same complex
Molecular Weight: 92297
Clone: Polyclonal
Gene Name: L3MBTL1
Gene ID: 26013
Function: Polycomb group (PcG) protein that specifically recognizes and binds mono- and dimethyllysine residues on target proteins, therey acting as a 'reader' of a network of post-translational modifications. PcG proteins maintain the transcriptionally repressive state of genes: acts as a chromatin compaction factor by recognizing and binding mono- and dimethylated histone H1b/H1-4 at 'Lys-26' (H1bK26me1 and H1bK26me2) and histone H4 at 'Lys-20' (H4K20me1 and H4K20me2), leading to condense chromatin and repress transcription. Recognizes and binds p53/TP53 monomethylated at 'Lys-382', leading to repress p53/TP53- target genes. Also recognizes and binds RB1/RB monomethylated at 'Lys- 860'. Participates in the ETV6-mediated repression. Probably plays a role in cell proliferation. Overexpression induces multinucleated cells, suggesting that it is required to accomplish normal mitosis.
Summary: Tissue Location: Widely expressed. Expression is reduced in colorectal cancer cell line SW480 and promyelocytic leukemia cell line HL-60.
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:2000
Synonyms: Lethal (3) malignant brain tumor-like protein 1, H-l (3) mbt, H-l (3) mbt protein, L (3) mbt-like, L (3) mbt protein homolog, L3MBTL1, L3MBTL1, KIAA0681, L3MBT, L3MBTL
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