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![Mouse Nkx2-5 Antibody (Center) [AMM06450G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/869731/1161798/logo__92149.1659788186__02441.1659865874.png?c=2 "Mouse Nkx2-5 Antibody (Center) [AMM06450G]"){kind=logo}
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Product Description
Mouse Nkx2-5 Antibody (Center) [AMM06450G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: M
Specificity: This mouse Nkx2-5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 192-235 amino acids from the Central region of mouse Nkx2-5.
Cellular Localisation: Nucleus.
Molecular Weight: 34163
Clone: Polyclonal
Gene Name: Nkx2-5
Gene ID: 18091
Function: Transcription factor required for the development of the heart and the spleen (PubMed:9584153, PubMed:19483677, PubMed:22560297) . During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4 (PubMed:9584153) . May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (PubMed:12023302) . Binds to the core DNA motif of NPPA promoter (PubMed:19483677) . Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression (PubMed:22560297) .
Summary: Tissue Location: Predominantly in the adult and embryonic heart, and to a lesser extent in lingual muscle, spleen and stomach
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Homeobox protein Nkx-25, Cardiac-specific homeobox, Homeobox protein CSX, Homeobox protein NK-2 homolog E, Nkx2-5, Csx, Nkx-25, Nkx2e
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