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Product Description
Mouse Pak3 Antibody (N-term) [APR31176G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: M
Specificity: This Mouse Pak3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 124-152 amino acids from the N-terminal region of mouse Pak3.
Cellular Localisation: Cytoplasm.
Molecular Weight: 62398
Clone: Polyclonal
Gene Name: Pak3
Gene ID: 18481
Function: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity (PubMed:25851601) . Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (PubMed:15800193) .
Summary: N/A
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: IHC-P, WB
Dilution: WB--1:1000 IHC-P--1:100~500
Synonyms: Serine/threonine-protein kinase PAK 3, Beta-PAK, CDC42/RAC effector kinase PAK-B, p21-activated kinase 3, PAK-3, Pak3, Pak-3, Pakb, Stk4
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