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Product Description
PCGF6 Antibody (Center) [APR33099G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: Rat
Specificity: This PCGF6 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 215-249 amino acids from the Central region of human PCGF6.
Cellular Localisation: Nucleus
Molecular Weight: 39047
Clone: Polyclonal
Gene Name: PCGF6
Gene ID: 84108
Function: Transcriptional repressor (PubMed:12167161) . May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase (PubMed:17320162) . Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167161) . Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332) .
Summary: Tissue Location: Ubiquitous.
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:2000
Synonyms: Polycomb group RING finger protein 6, Mel18 and Bmi1-like RING finger, RING finger protein 134, PCGF6, MBLR, RNF134
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