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Product Description
CANX Antibody (C-Term) [APR33574G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M, Rat
Specificity: This CANX antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 560-592 amino acids from human CANX.
Cellular Localisation: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endoplasmic reticulum Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065) . The palmitoylated form preferentially localizes to the perinuclear rough ER (PubMed:22314232) .
Molecular Weight: 67568
Clone: Polyclonal
Gene Name: CANX
Gene ID: 821
Function: Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
Summary: N/A
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB, FC, IHC-P
Dilution: IHC-P--1:100~500 FC--1:25 WB--1:2000
Synonyms: Calnexin, IP90, Major histocompatibility complex class I antigen-binding protein p88, p90, CANX
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