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Product Description
DNMT3L Antibody (C-term) [APR31426G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This DNMT3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 355-381 amino acids from the C-terminal region of human DNMT3L.
Cellular Localisation: Nucleus.
Molecular Weight: 43583
Clone: Polyclonal
Gene Name: DNMT3L
Gene ID: 29947
Function: Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context (By similarity) . Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain (PubMed:17687327) . Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases (PubMed:17687327) . Recognizes unmethylated histone H3 lysine 4 (H3K4me0) and induces de novo DNA methylation by recruitment or activation of DNMT3 (PubMed:17687327) . Plays a key role in embryonic stem cells and germ cells (By similarity) . In germ cells, required for the methylation of imprinted loci together with DNMT3A (By similarity) . In male germ cells, specifically required to methylate retrotransposons, preventing their mobilization (By similarity) . Plays a key role in embryonic stem cells (ESCs) by acting both as an positive and negative regulator of DNA methylation (By similarity) . While it promotes DNA methylation of housekeeping genes together with DNMT3A and DNMT3B, it also acts as an inhibitor of DNA methylation at the promoter of bivalent genes (By similarity) . Interacts with the EZH2 component of the PRC2/EED-EZH2 complex, preventing interaction of DNMT3A and DNMT3B with the PRC2/EED-EZH2 complex, leading to maintain low methylation levels at the promoters of bivalent genes (By similarity) . Promotes differentiation of ESCs into primordial germ cells by inhibiting DNA methylation at the promoter of RHOX5, thereby activating its expression (By similarity) .
Summary: Tissue Location: Expressed at low levels in several tissues including testis, ovary, and thymus.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: DNA (cytosine-5) -methyltransferase 3-like, DNMT3L
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