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Product Description
FEM1B Antibody (C-Term) [APR33463G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M, Rat
Specificity: This FEM1B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 547-579 amino acids from human FEM1B.
Cellular Localisation: Cytoplasm. Nucleus Note=In the nucleus, the protein level increased slightly after camptothecin (CPT) treatment (PubMed:19330022) . Associated with chromatin (PubMed:19330022) .
Molecular Weight: 70264
Clone: Polyclonal
Gene Name: FEM1B {ECO:0000303|PubMed:10623617, ECO:0000312|HGNC:HGNC:3649}
Gene ID: 10116
Function: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948, PubMed:33398170, PubMed:33398168) . The C- degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29779948, PubMed:33398170, PubMed:33398168) . The CRL2 (FEM1B) complex specifically recognizes proteins ending with -Gly-Leu-Asp-Arg, such as CDK5R1, leading to their ubiquitination and degradation (PubMed:33398170, PubMed:33398168) . Also acts as a regulator of the reductive stress response by mediating ubiquitination of reduced FNIP1: in response to reductive stress, the CRL2 (FEM1B) complex specifically recognizes a conserved Cys degron in FNIP1 when this degron is reduced, leading to FNIP1 degradation and subsequent activation of mitochondria to recalibrate reactive oxygen species (ROS) (By similarity) . Promotes ubiquitination of GLI1, suppressing GLI1 transcriptional activator activity (PubMed:24076122) . Promotes ubiquitination and degradation of ANKRD37 (By similarity) . Promotes ubiquitination and degradation of SLBP (PubMed:28118078) . Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis (PubMed:10542291) . Also involved in glucose homeostasis in pancreatic islet (By similarity) . May also act as an adapter/mediator in replication stress- induced signaling that leads to the activation of CHEK1 (PubMed:19330022) .
Summary: Tissue Location: Widely expressed (PubMed:10542291) . Highly expressed in testis (PubMed:10542291) . Weakly expressed in other tissues (PubMed:10542291) .
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:2000
Synonyms: Protein fem-1 homolog B, FEM1b, FEM1-beta, Fem-1-like death receptor-binding protein alpha, Fem-1-like in apoptotic pathway protein alpha, F1A-alpha, FEM1B, F1AA, KIAA0396
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