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Product Description
LASS6 Antibody (C-term) [APR31568G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This LASS6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 335-361 amino acids from the C-terminal region of human LASS6.
Cellular Localisation: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8C172}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8C172}
Molecular Weight: 44890
Clone: Polyclonal
Gene Name: CERS6 (HGNC:23826)
Gene ID: 253782
Function: Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) (PubMed:17977534, PubMed:17609214, PubMed:23530041, PubMed:26887952, PubMed:31916624) . Can use other acyl donors, but with less efficiency (By similarity) . N- acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (PubMed:17977534, PubMed:23530041, PubMed:26887952, PubMed:31916624) . Ceramides generated by CERS6 play a role in inflammatory response (By similarity) . Acts as a regulator of metabolism and hepatic lipid accumulation (By similarity) . Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity (By similarity) .
Summary: N/A
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Ceramide synthase 6, CerS6, LAG1 longevity assurance homolog 6, CERS6, LASS6
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