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Product Description
Mouse Camk1d Antibody (N-term) [APR32802G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This Mouse Camk1d antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-67 amino acids from the N-terminal region of mouse Camk1d.
Cellular Localisation: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear upon activation.
Molecular Weight: 42919
Clone: Polyclonal
Gene Name: Camk1d
Gene ID: 227541
Function: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium- mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta (By similarity) . Isoform 1 but not isoform 2 activates CREB1.
Summary: Tissue Location: Expressed ubiquitously with high levels in brain and low levels in kidney. Isoform 2 is highly expressed in brain compared to other tissues. In hematopoietic cell lines predominant expression was detected in T and EC cells
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Calcium/calmodulin-dependent protein kinase type 1D, CaM kinase I delta, CaM-KI delta, CaMKI delta, CaM kinase ID, CaMKI-like protein kinase, CKLiK, mCKLiK, Camk1d
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