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Product Description
NSFL1C Antibody (N-Term) [APR33519G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This NSFL1C antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 37-71 amino acids from human NSFL1C.
Cellular Localisation: Nucleus {ECO:0000250|UniProtKB:O35987}. Golgi apparatus, Golgi stack {ECO:0000250|UniProtKB:O35987}. Chromosome {ECO:0000250|UniProtKB:O35987}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:O35987} Note=Predominantly nuclear in interphase cells. Bound to the axial elements of sex chromosomes in pachytene spermatocytes. A small proportion of the protein is cytoplasmic, associated with Golgi stacks Localizes to centrosome during mitotic prophase and metaphase {ECO:0000250|UniProtKB:O35987}
Molecular Weight: 40573
Clone: Polyclonal
Gene Name: NSFL1C
Gene ID: 55968
Function: Reduces the ATPase activity of VCP (By similarity) . Necessary for the fragmentation of Golgi stacks during mitosis and for VCP- mediated reassembly of Golgi stacks after mitosis (By similarity) . May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity) . Inhibits the activity of CTSL (in vitro) (PubMed:15498563) . Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807) . Also, regulates spindle orientation during mitosis (PubMed:23649807) .
Summary: N/A
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB, IHC-P, FC
Dilution: FC--1:25 IHC-P--1:100~500 WB--1:2000
Synonyms: NSFL1 cofactor p47, UBX domain-containing protein 2C, p97 cofactor p47, NSFL1C, UBXN2C
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