Euro
USD
British Pound
NULL
![PCGF6 Antibody (Center) [APR31728G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/871973/1164040/logo__92149.1659788186__89597.1659868282.png?c=2 "PCGF6 Antibody (Center) [APR31728G]"){kind=logo}
![PCGF6 Antibody (Center) [APR31728G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/871973/1164040/logo__92149.1659788186__89597.1659868282.png?c=2 "PCGF6 Antibody (Center) [APR31728G]"){kind=logo}
Product Description
PCGF6 Antibody (Center) [APR31728G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, Rat
Specificity: This PCGF6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 190-217 amino acids from the Central region of human PCGF6.
Cellular Localisation: Nucleus
Molecular Weight: 39047
Clone: Polyclonal
Gene Name: PCGF6
Gene ID: 84108
Function: Transcriptional repressor (PubMed:12167161) . May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase (PubMed:17320162) . Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:12167161) . Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332) .
Summary: Tissue Location: Ubiquitous.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Polycomb group RING finger protein 6, Mel18 and Bmi1-like RING finger, RING finger protein 134, PCGF6, MBLR, RNF134
![PCGF6 Antibody (Center) [APR31728G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/871973/1164040/logo__92149.1659788186__89597.1659868282.png?c=2 "PCGF6 Antibody (Center) [APR31728G]"){kind=logo}
![PCGF6 Antibody (Center) [APR33099G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/873344/1165411/logo__92149.1659788186__50271.1659869022.png?c=2 "PCGF6 Antibody (Center) [APR33099G]"){kind=logo}
