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Product Description
PTGDR Antibody (C-Term) [APR33580G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This PTGDR antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 306-348 amino acids from human PTGDR.
Cellular Localisation: Cell membrane; Multi-pass membrane protein
Molecular Weight: 40271
Clone: Polyclonal
Gene Name: PTGDR
Gene ID: 5729
Function: Receptor for prostaglandin D2 (PGD2) . The activity of this receptor is mainly mediated by G (s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1, 4, 5-trisphosphate (By similarity) . Involved in PLA2G3- dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity) .
Summary: Tissue Location: Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes.
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:2000
Synonyms: Prostaglandin D2 receptor, PGD receptor, PGD2 receptor, Prostanoid DP receptor, PTGDR
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