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Product Description
SH3GL2 Antibody (C-term) [APR33203G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M, Rat
Specificity: This SH3GL2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 245-279 amino acids from the C-terminal region of human SH3GL2.
Cellular Localisation: Cytoplasm {ECO:0000250|UniProtKB:O35179}. Membrane {ECO:0000250|UniProtKB:O35179}; Peripheral membrane protein {ECO:0000250|UniProtKB:O35179}. Early endosome {ECO:0000250|UniProtKB:Q62420}. Cell junction, synapse, presynapse {ECO:0000250|UniProtKB:O35179}
Molecular Weight: 39962
Clone: Polyclonal
Gene Name: SH3GL2
Gene ID: 6456
Function: Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.
Summary: Tissue Location: Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:2000
Synonyms: Endophilin-A1, EEN-B1, Endophilin-1, SH3 domain protein 2A, SH3 domain-containing GRB2-like protein 2, SH3GL2, CNSA2, SH3D2A
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