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![SLC1A3 Antibody (N-Term) [APR33543G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/873788/1165855/logo__92149.1659788186__47822.1659869200.png?c=2 "SLC1A3 Antibody (N-Term) [APR33543G]"){kind=logo}
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Product Description
SLC1A3 Antibody (N-Term) [APR33543G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M
Specificity: This SLC1A3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 127-161 amino acids from human SLC1A3.
Cellular Localisation: Cell membrane; Multi-pass membrane protein
Molecular Weight: 59572
Clone: Polyclonal
Gene Name: SLC1A3
Gene ID: 6507
Function: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515) . Functions as a symporter that transports one amino acid molecule together with two or three Na (+) ions and one proton, in parallel with the counter-transport of one K (+) ion (PubMed:20477940) . Mediates Cl (-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na (+) symport (PubMed:20477940) . Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity) .
Summary: Tissue Location: Detected in brain (PubMed:8218410, PubMed:7521911, PubMed:8123008) . Detected at very much lower levels in heart, lung, placenta and skeletal muscle (PubMed:7521911, PubMed:8123008) . Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia (PubMed:7521911) .
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:8000
Synonyms: Excitatory amino acid transporter 1, Sodium-dependent glutamate/aspartate transporter 1, GLAST-1, Solute carrier family 1 member 3, SLC1A3, EAAT1, GLAST, GLAST1
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