Product Description
ST3GAL4 Antibody (N-Term) [APR33441G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This ST3GAL4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 26-57 amino acids from human ST3GAL4.
Cellular Localisation: Golgi apparatus, Golgi stack membrane; Single- pass type II membrane protein. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid
Molecular Weight: 38045
Clone: Polyclonal
Gene Name: ST3GAL4
Gene ID: 6484
Function: A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:8288606, PubMed:8611500) . Catalyzes the transfer of sialic acid (N-acetyl- neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta- (1->3) -GalNAc- and Galbeta- (1->4) -GlcNAc- terminated glycoconjugates through an alpha2-3 linkage (PubMed:8288606, PubMed:8611500) . Plays a major role in hemostasis. Responsible for sialylation of plasma VWF/von Willebrand factor, preventing its recognition by asialoglycoprotein receptors (ASGPR) and subsequent clearance. Regulates ASGPR-mediated clearance of platelets (By similarity) . Participates in the biosynthesis of the sialyl Lewis X epitopes, both on O- and N-glycans, which are recognized by SELE/E- selectin, SELP/P-selectin and SELL/L-selectin. Essential for selectin- mediated rolling and adhesion of leukocytes during extravasation (PubMed:25498912) . Contributes to adhesion and transendothelial migration of neutrophils likely through terminal sialylation of CXCR2 (By similarity) . In glycosphingolipid biosynthesis, sialylates GM1 and GA1 gangliosides to form GD1a and GM1b, respectively (PubMed:8288606) . Metabolizes brain c-series ganglioside GT1c forming GQ1c (By similarity) . Synthesizes ganglioside LM1 (IV3Neu5Ac-nLc4Cer), a major structural component of peripheral nerve myelin (PubMed:8611500) .
Summary: Tissue Location: Highly expressed in adult placenta, heart and kidney.
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000-1:2000
Synonyms: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 3-sialyltransferase 4, Alpha 2, 3-ST 4, Beta-galactoside alpha-2, 3-sialyltransferase 4, 2.4.99.-, Alpha 2, 3-sialyltransferase IV, Gal-NAc6S, Gal-beta-1, 4-GalNAc-alpha-2, 3-sialyltransferase, SAT-3, ST-4, ST3Gal IV, ST3GalIV, ST3GalA.2, STZ, Sialyltransferase 4C, SIAT4-C, ST3GAL4, CGS23, NANTA3, SIAT4C, STZ