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Product Description
ST8SIA1 Antibody (N-Term) [APR33542G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This ST8SIA1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 53-84 amino acids from human ST8SIA1.
Cellular Localisation: Golgi apparatus membrane; Single- pass type II membrane protein
Molecular Weight: 40519
Clone: Polyclonal
Gene Name: ST8SIA1
Gene ID: 6489
Function: Catalyzes the addition of sialic acid in alpha 2, 8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid (PubMed:7937974, PubMed:8058740, PubMed:8195250, PubMed:8631981, PubMed:8706663, PubMed:18348864, PubMed:22885356) . Can catalyze the addition of a second alpha-2, 8- sialic acid to GD3 to form GT3 (PubMed:8631981) . Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively (PubMed:8706663) . Can synthesize unusual tetra- and pentasialylated lactosylceramide derivatives identified as GQ3 (II3Neu5Ac4-Gg2Cer) and GP3 (II3Neu5Ac5-Gg2Cer) in breast cancer cells (PubMed:22885356) .
Summary: Tissue Location: Strongly expressed in melanoma cell lines, adult and fetal brain and to a lesser extent in adult and fetal lung
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB, FC
Dilution: FC--1:25 WB--1:1000-1:2000
Synonyms: Alpha-N-acetylneuraminide alpha-2, 8-sialyltransferase, 2.4.99.8, Alpha-2, 8-sialyltransferase 8A, Ganglioside GD3 synthase, Ganglioside GT3 synthase, Sialyltransferase 8A, SIAT8-A, Sialyltransferase St8Sia I, ST8SiaI, ST8SIA1, SIAT8, SIAT8A
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