Product Description
USP45 Antibody (Center) [APR31114G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M
Specificity: This USP45 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 309-338 amino acids from the Central region of human USP45.
Cellular Localisation: Photoreceptor inner segment. Cytoplasm Nucleus
Molecular Weight: 91733
Clone: Polyclonal
Gene Name: USP45
Gene ID: 85015
Function: Catalyzes the deubiquitination of SPDL1 (PubMed:30258100) . Plays a role in the repair of UV-induced DNA damage via deubiquitination of ERCC1, promoting its recruitment to DNA damage sites (PubMed:25538220) . May be involved in the maintenance of photoreceptor function (PubMed:30573563) . May play a role in normal retinal development (By similarity) . Plays a role in cell migration (PubMed:30258100) .
Summary: Tissue Location: Widely expressed. High expression is detected in the cerebellum. In the eye, it is expressed at high levels in the optic nerve, sclera and retina, with relatively low levels in the choroid, lens and retinal pigment epithelium (PubMed:30573563)
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P
Dilution: WB--1:2000 WB--1:1000 IHC-P--1:100~500
Synonyms: Ubiquitin carboxyl-terminal hydrolase 45, Deubiquitinating enzyme 45, Ubiquitin thioesterase 45, Ubiquitin-specific-processing protease 45, USP45