Euro
USD
British Pound
NULL
![CD71 Antibody (C-term) [APG02505G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/866858/1158925/logo__92149.1659788186__06248.1659863400.png?c=2 "CD71 Antibody (C-term) [APG02505G]"){kind=logo}
![CD71 Antibody (C-term) [APG02505G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/866858/1158925/logo__92149.1659788186__06248.1659863400.png?c=2 "CD71 Antibody (C-term) [APG02505G]"){kind=logo}
Product Description
CD71 Antibody (C-term) [APG02505G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This CD71 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 649-677 amino acids from the C-terminal region of human CD71.
Cellular Localisation: Cell membrane; Single-pass type II membrane protein Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
Molecular Weight: 84871
Clone: Polyclonal
Gene Name: TFRC
Gene ID: 7037
Function: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed:26214738) . Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity) . A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240) . Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (PubMed:26214738) . When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (PubMed:26214738) . When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (PubMed:26214738) .
Summary: N/A
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P, FC
Dilution: IHC-P--1:100~500 WB--1:2000
Synonyms: Transferrin receptor protein 1, TR, TfR, TfR1, Trfr, T9, p90, CD71, Transferrin receptor protein 1, serum form, sTfR, TFRC
![CD71 Antibody (C-term) [APG02505G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/866858/1158925/logo__92149.1659788186__06248.1659863400.png?c=2 "CD71 Antibody (C-term) [APG02505G]"){kind=logo}
![Aurora-C Antibody (C-term) [APR32362G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/872607/1164674/logo__92149.1659788186__46763.1659868725.png?c=2 "Aurora-C Antibody (C-term) [APR32362G]"){kind=logo}
![c-fos Antibody (C-term) [APR32301G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/872546/1164613/logo__92149.1659788186__49531.1659868701.png?c=2 "c-fos Antibody (C-term) [APR32301G]"){kind=logo}
![c-KIT Antibody (C-term) [APR30524G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/870769/1162836/logo__92149.1659788186__87736.1659866868.png?c=2 "c-KIT Antibody (C-term) [APR30524G]"){kind=logo}
![BMP8B Antibody (C-Term) [APR33622G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/873867/1165934/logo__92149.1659788186__15349.1659869232.png?c=2 "BMP8B Antibody (C-Term) [APR33622G]"){kind=logo}