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Product Description
DNAJB9 Antibody (N-term) [APR15771G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M
Specificity: This DNAJB9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-69 amino acids from the N-terminal region of human DNAJB9.
Cellular Localisation: Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:Q9QYI6}
Molecular Weight: 25518
Clone: Polyclonal
Gene Name: DNAJB9
Gene ID: 4189
Function: Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity) . J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:18400946) . In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity) . Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B- cell progenitors and normal antibody production (By similarity) .
Summary: Tissue Location: Widely expressed. Expressed at highest level in the liver, placenta and kidney (PubMed:11836248)
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: DnaJ homolog subfamily B member 9, Endoplasmic reticulum DNA J domain-containing protein 4, ER-resident protein ERdj4, ERdj4, Microvascular endothelial differentiation gene 1 protein, Mdg-1, DNAJB9, MDG1
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