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Product Description
GSDMA Antibody (N-term) [APR05359G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M
Specificity: This GSDMA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the N-terminal region of human GSDMA.
Cellular Localisation: [Gasdermin-A]: Cytoplasm, perinuclear region. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5Y4Y6}
Molecular Weight: 49365
Clone: Polyclonal
Gene Name: GSDMA (HGNC:13311)
Gene ID: 284110
Function: [Gasdermin-A]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-A, N-terminal) binds to membranes and forms pores, triggering cell death.
Summary: Tissue Location: Expressed predominantly in the gastrointestinal tract and, at a lower level, in the skin. Also detected in mammary gland. In the gastrointestinal tract, mainly expressed in differentiated cells, including the differentiated cell layer of esophagus and mucus-secreting pit cells of the gastric epithelium Down-regulateded in gastric cancer cells.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P, FC
Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50
Synonyms: Gasdermin-A, Gasdermin-1, GSDMA, GSDM, GSDM1
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