Euro
USD
British Pound
NULL
![HK2 (Hexokinase II) Antibody (Center) [APR07762G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/868533/1160600/logo__92149.1659788186__18704.1659864418.png?c=2 "HK2 (Hexokinase II) Antibody (Center) [APR07762G]"){kind=logo}
![HK2 (Hexokinase II) Antibody (Center) [APR07762G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/868533/1160600/logo__92149.1659788186__18704.1659864418.png?c=2 "HK2 (Hexokinase II) Antibody (Center) [APR07762G]"){kind=logo}
Product Description
HK2 (Hexokinase II) Antibody (Center) [APR07762G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This HK2 (Hexokinase II) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 453-483 amino acids from the Central region of human HK2 (Hexokinase II) .
Cellular Localisation: Mitochondrion outer membrane; Peripheral membrane protein. Cytoplasm, cytosol Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane (PubMed:29298880) The interaction with the mitochondrial outer membrane via the mitochondrial-binding peptide (MBP) region promotes higher stability of the protein (PubMed:29298880) . Release from the mitochondrial outer membrane into the cytosol induces permeability transition pore (PTP) opening and apoptosis (PubMed:18350175) .
Molecular Weight: 102380
Clone: Polyclonal
Gene Name: HK2 (HGNC:4923)
Gene ID: 3099
Function: Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880) . Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:29298880) . Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (PubMed:18350175) .
Summary: Tissue Location: Predominant hexokinase isozyme expressed in insulin-responsive tissues such as skeletal muscle
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P
Dilution: IHC-P--1:100 WB--1:1000
Synonyms: Hexokinase-2, Hexokinase type II, HK II, Muscle form hexokinase, HK2
![HK2 (Hexokinase II) Antibody (Center) [APR07762G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/868533/1160600/logo__92149.1659788186__18704.1659864418.png?c=2 "HK2 (Hexokinase II) Antibody (Center) [APR07762G]"){kind=logo}
![HK2 (Hexokinase II) Antibody [AMM22224G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/870585/1162652/logo__92149.1659788186__99918.1659866715.png?c=2 "HK2 (Hexokinase II) Antibody [AMM22224G]"){kind=logo}
![HK2 (Hexokinase II) Antibody (N-term) [APR07115G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/868532/1160599/logo__92149.1659788186__66560.1659864417.png?c=2 "HK2 (Hexokinase II) Antibody (N-term) [APR07115G]"){kind=logo}
