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Product Description
IPO11 Antibody (C-term) [APR16881G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This IPO11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 891-920 amino acids from the C-terminal region of human IPO11.
Cellular Localisation: Cytoplasm. Nucleus
Molecular Weight: 112535
Clone: Polyclonal
Gene Name: IPO11
Gene ID: 51194
Function: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity) . Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity) .
Summary: N/A
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Importin-11, Imp11, Ran-binding protein 11, RanBP11, IPO11, RANBP11
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