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Product Description
LAPTM4B Antibody [APR04710G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, Rat
Specificity: This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 195-209 amino acids from human.
Cellular Localisation: Endomembrane system; Multi-pass membrane protein. Late endosome membrane. Cell membrane. Cell projection. Lysosome membrane. Endosome membrane. Endosome, multivesicular body membrane. Endosome, multivesicular body lumen
Molecular Weight: 35123
Clone: Polyclonal
Gene Name: LAPTM4B (HGNC:13646)
Gene ID: 55353
Function: Required for optimal lysosomal function (PubMed:21224396) . Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4, 5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945) . Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V) -ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567) . Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825) . Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656) .
Summary: N/A
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:250 WB--1:1000
Synonyms: Lysosomal-associated transmembrane protein 4B, Lysosome-associated transmembrane protein 4-beta, LAPTM4B
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