Euro
USD
British Pound
NULL
![MICAL2 Antibody (N-term) [APR06180G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/868900/1160967/logo__92149.1659788186__96713.1659864572.png?c=2 "MICAL2 Antibody (N-term) [APR06180G]"){kind=logo}
![MICAL2 Antibody (N-term) [APR06180G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/868900/1160967/logo__92149.1659788186__96713.1659864572.png?c=2 "MICAL2 Antibody (N-term) [APR06180G]"){kind=logo}
Product Description
MICAL2 Antibody (N-term) [APR06180G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This MICAL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the N-terminal region of human MICAL2.
Cellular Localisation: Nucleus.
Molecular Weight: 126689
Clone: Polyclonal
Gene Name: MICAL2
Gene ID: 9645
Function: Nuclear monooxygenase that promotes depolymerization of F- actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:24440334) . In the absence of actin, it also functions as a NADPH oxidase producing H (2) O (2) (By similarity) . Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A- dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (PubMed:24440334) .
Summary: N/A
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Protein-methionine sulfoxide oxidase MICAL2, 11413-, Molecule interacting with CasL protein 2, MICAL-2, MICAL2, KIAA0750, MICAL2PV1, MICAL2PV2
![MICAL2 Antibody (N-term) [APR06180G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/868900/1160967/logo__92149.1659788186__96713.1659864572.png?c=2 "MICAL2 Antibody (N-term) [APR06180G]"){kind=logo}
