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Product Description
Mouse Ephb4 Antibody (C-term) [AMM06438G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M
Specificity: This Mouse Ephb4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 889-923 amino acids from the C-terminal region of Mouse Ephb4.
Cellular Localisation: Cell membrane {ECO:0000250|UniProtKB:P54760}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P54760}
Molecular Weight: 108848
Clone: Polyclonal
Gene Name: Ephb4
Gene ID: 13846
Function: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells.
Summary: Tissue Location: Expressed in various organ systems, including lung, liver, kidney, intestine, muscle and heart (PubMed:7478528) . Expressed in myogenic progenitor cells (PubMed:27446912)
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Ephrin type-B receptor 4, Developmental kinase 2, mDK-2, Hepatoma transmembrane kinase, Tyrosine kinase MYK-1, Ephb4, Htk, Mdk2, Myk1
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