Euro
USD
British Pound
NULL
![Phospho-p27Kip1 (T187) Antibody [APR05144G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/866929/1158996/logo__92149.1659788186__82026.1659863429.png?c=2 "Phospho-p27Kip1 (T187) Antibody [APR05144G]"){kind=logo}
![Phospho-p27Kip1 (T187) Antibody [APR05144G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/866929/1158996/logo__92149.1659788186__82026.1659863429.png?c=2 "Phospho-p27Kip1 (T187) Antibody [APR05144G]"){kind=logo}
Product Description
Phospho-p27Kip1 (T187) Antibody [APR05144G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This p27Kip1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T187 of human p27Kip1.
Cellular Localisation: Nucleus. Cytoplasm. Endosome. Note=Nuclear and cytoplasmic in quiescent cells. AKT- or RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By similarity)
Molecular Weight: 22073
Clone: Polyclonal
Gene Name: CDKN1B
Gene ID: 1027
Function: Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995) . Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry.
Summary: Tissue Location: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P
Dilution: WB--1:1000 IHC-P--1:100~500
Synonyms: Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, p27Kip1, CDKN1B, KIP1
![Phospho-p27Kip1 (T187) Antibody [APR05144G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/866929/1158996/logo__92149.1659788186__82026.1659863429.png?c=2 "Phospho-p27Kip1 (T187) Antibody [APR05144G]"){kind=logo}
