Product Description
RGS2 Antibody (N-term) [APR04526G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This RGS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-32 amino acids from the N-terminal region of human RGS2.
Cellular Localisation: [Isoform 1]: Cell membrane. Cytoplasm. Nucleus, nucleolus [Isoform 3]: Cell membrane. Cytoplasm Nucleus, nucleolus
Molecular Weight: 24382
Clone: Polyclonal
Gene Name: RGS2
Gene ID: 5997
Function: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form (PubMed:11063746, PubMed:19478087) . It is involved in the negative regulation of the angiotensin-activated signaling pathway (PubMed:28784619) . Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity) . Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320) .
Summary: Tissue Location: Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL) .
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Regulator of G-protein signaling 2, RGS2, Cell growth-inhibiting gene 31 protein, G0/G1 switch regulatory protein 8, RGS2, G0S8