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Product Description
SELT Antibody (N-term) [APR06158G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This SELT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-75 amino acids from the N-terminal region of human SELT.
Cellular Localisation: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q1H5H1}; Single-pass membrane protein
Molecular Weight: 22324
Clone: Polyclonal
Gene Name: SELENOT {ECO:0000303|PubMed:27645994, ECO:0000312|HGNC:HGNC:18136}
Gene ID: 51714
Function: Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity) . Protects dopaminergic neurons against oxidative stress ans cell death (PubMed:26866473) . Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity) . Plays a role in fibroblast anchorage and redox regulation (By similarity) . In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity) . In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP- induced insulin secretion (By similarity) .
Summary: Tissue Location: Ubiquitous. Highly expressed in the endocrine pancreas.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, FC
Dilution: WB--1:1000 FC--1:10~50
Synonyms: Selenoprotein T, SelT, SELT
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