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Product Description
SIDT2 Antibody (Center) [APR03841G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M
Specificity: This SIDT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 418-447 amino acids from the Central region of human SIDT2.
Cellular Localisation: Lysosome membrane; Multi-pass membrane protein. Cell membrane. Note=Mainly localizes to lysosomes and only partly to the plasma membrane (PubMed:28277980) . Lysosomal localization is required for SIDT2-mediated intracellular degradation of endogenous RNA (By similarity) . {ECO:0000250|UniProtKB:Q8CIF6, ECO:0000269|PubMed:28277980}
Molecular Weight: 94454
Clone: Polyclonal
Gene Name: SIDT2
Gene ID: 51092
Function: Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP- dependent manner, and degraded (PubMed:27046251, PubMed:27846365) . Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis (PubMed:28277980) . In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (By similarity) .
Summary: N/A
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: SID1 transmembrane family member 2, SIDT2
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