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Product Description
SLCO1B1 Antibody (Center) [APR10154G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This SLCO1B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-293 amino acids from the Central region of human SLCO1B1.
Cellular Localisation: Basolateral cell membrane; Multi-pass membrane protein. Note=Detected in basolateral membranes of hepatocytes
Molecular Weight: 76449
Clone: Polyclonal
Gene Name: SLCO1B1
Gene ID: 10599
Function: Mediates the Na (+) -independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.
Summary: Tissue Location: Highly expressed in liver, at the basolateral membranes of centrilobular hepatocytes. Not detected in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocyte
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:500
Synonyms: Solute carrier organic anion transporter family member 1B1, Liver-specific organic anion transporter 1, LST-1, OATP-C, Sodium-independent organic anion-transporting polypeptide 2, OATP-2, Solute carrier family 21 member 6, SLCO1B1, LST1, OATP1B1, OATP2, OATPC, SLC21A6
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