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Product Description
SREBF1 Antibody (Center) [APR10237G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This SREBF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 349-378 amino acids of human SREBF1.
Cellular Localisation: [Sterol regulatory element-binding protein 1]: Endoplasmic reticulum membrane; Multi- pass membrane protein. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9WTN3}; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:Q9WTN3}; Multi-pass membrane protein. Note=At high sterol concentrations, the SCAP-SREBP is retained in the endoplasmic reticulum. Low sterol concentrations promote recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi, where it is processed {ECO:0000250|UniProtKB:Q9WTN3} [Isoform SREBP-1aDelta]: Nucleus
Molecular Weight: 121675
Clone: Polyclonal
Gene Name: SREBF1 {ECO:0000303|PubMed:7759101, ECO:0000312|HGNC:HGNC:11289}
Gene ID: 6720
Function: [Sterol regulatory element-binding protein 1]: Precursor of the transcription factor form (Processed sterol regulatory element- binding protein 1), which is embedded in the endoplasmic reticulum membrane (PubMed:32322062) . Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis and lipid homeostasis (By similarity) .
Summary: Tissue Location: Expressed in a wide variety of tissues, most abundant in liver and adrenal gland (PubMed:8402897) . In fetal tissues lung and liver shows highest expression (PubMed:8402897) [Isoform SREBP-1C]: Predominantly expressed in liver and adipose tissues (PubMed:8402897) . Also expressed in kidney, brain, white fat, and muscle (PubMed:8402897)
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P, FC
Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50
Synonyms: Sterol regulatory element-binding protein 1, SREBP-1, Class D basic helix-loop-helix protein 1, bHLHd1, Sterol regulatory element-binding transcription factor 1, Processed sterol regulatory element-binding protein 1, SREBF1, BHLHD1, SREBP1
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