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Product Description
TCF7L1 Antibody (N-term) [AMM08693G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This TCF7L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-98 amino acids from the N-terminal region of human TCF7L1.
Cellular Localisation: Nucleus.
Molecular Weight: 62631
Clone: Polyclonal
Gene Name: TCF7L1
Gene ID: 83439
Function: Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity) . Down-regulates NQO1, leading to increased mitomycin c resistance.
Summary: Tissue Location: Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Transcription factor 7-like 1, HMG box transcription factor 3, TCF-3, TCF7L1, TCF3
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